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Olcegepant (hydrochloride)

CAS No. 586368-06-1

Olcegepant (hydrochloride) ( BIBN-4096 hydrochloride;BIBN-4096BS hydrochloride )

Catalog No. M15157 CAS No. 586368-06-1

The first small molecule selective CGRP antagonist with Ki of 14.4 nM for hCGRP.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Olcegepant (hydrochloride)
  • Note
    Research use only, not for human use.
  • Brief Description
    The first small molecule selective CGRP antagonist with Ki of 14.4 nM for hCGRP.
  • Description
    The first small molecule selective CGRP antagonist with Ki of 14.4 nM for hCGRP; inhibits the effects of CGRP, released by stimulation of the trigeminal ganglion, on facial blood flow in marmoset monkeys (1-30mg/kg, i.v.).
  • Synonyms
    BIBN-4096 hydrochloride;BIBN-4096BS hydrochloride
  • Pathway
    GPCR/G Protein
  • Target
    CGRP Receptor
  • Recptor
    CGRP Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    586368-06-1
  • Formula Weight
    906.11
  • Molecular Formula
    C38H47Br2N9O5.HCl
  • Purity
    >98% (HPLC)
  • Solubility
    H2O: ≥ 66.66 mg/mL
  • SMILES
    C1CN(CCC1N2CC3=CC=CC=C3NC2=O)C(=O)NC(CC4=CC(=C(C(=C4)Br)O)Br)C(=O)NC(CCCCN)C(=O)N5CCN(CC5)C6=CC=NC=C6.Cl
  • Chemical Name
    1-Piperidinecarboxamide, N-[(1R)-2-[[(1S)-5-amino-1-[[4-(4-pyridinyl)-1-piperazinyl]carbonyl]pentyl]amino]-1-[(3,5-dibromo-4-hydroxyphenyl)methyl]-2-oxoethyl]-4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl)-, hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Doods H, et al. Br J Pharmacol. 2000 Feb;129(3):420-3.
2. Powell KJ, et al. Br J Pharmacol. 2000 Nov;131(5):875-84.
3. Edvinsson L, et al. Eur J Pharmacol. 2002 Jan 2;434(1-2):49-53.
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